Home  >  Products  >  GITRL (Tumor Necrosis Factor Ligand Superfamily Member 18, Activation-inducible TNF-related Ligand, AITRL, Glucocorticoid-induced TNF-related Ligand, hGITRL, TNFSF18, AITRL, GITR, TL6, UNQ149/PRO175)
GITRL (Tumor Necrosis Factor Ligand Superfamily Member 18, Activation-inducible TNF-related Ligand, AITRL, Glucocorticoid-induced TNF-related Ligand, hGITRL, TNFSF18, AITRL, GITR, TL6, UNQ149/PRO175)

GITRL (Tumor Necrosis Factor Ligand Superfamily Member 18, Activation-inducible TNF-related Ligand, AITRL, Glucocorticoid-induced TNF-related Ligand, hGITRL, TNFSF18, AITRL, GITR, TL6, UNQ149/PRO175)

Cat no: G2035-09N

Supplier: United States Biological
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GITR or TNFRSF18 is a 241aa novel member of the tumor necrosis factor receptor superfamily and a receptor for TNFSF18. It has three extracytoplasmic cysteine-rich pseudorepeats, a small cytoplasmic tail and a DEATH domain. It is an essential regulator of immune responses to self tissues and pathogens and plays a key role in dominant immunological self-tolerance maintained by CD25 (+) CD4 (+) regulatory T cells. It is known to be involved in regulation of CD3-driven T-cell activation and programmed cell death and also in interactions between activated T-lymphocytes and endothelial cells. In mammalian cells it mediates NF-kappa-B activation via TRAF2 and modulates T lymphocyte survival in peripheral tissues. It is mostly expressed in lymph node, peripheral blood leukocytes and weakly expressed in spleen. GITR and its ligand are also known to be involved in atopic dermatitis. Applications: Suitable for use in Flow Cytometry and Immunoprecipitation. Other applications not tested. Recommended Dilution: Flow Cytometry: 0.1-0.5ug/10e6 cells Optimal dilutions to be determined by the researcher. Positive Control: C57 mouse splenocytes Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: G2035-09N
Reactivities: Mouse
Hosts: Rat
Applications: Flow Cytometry, Immunoprecipitation
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Mab
Isotype: IgG2b,l
Purity: Purified by Protein G affinity chromatography.
References: 1. Esparza, EM. et al. J. Immonol. 174:7875-7882 (2005). 2. Bushell, A. et al. Am. Transplant. 7:759-768 (2007). 3. Kwon, B. et al. J. Biol. Chem. 274:6056-6061 (1999).
Additional info: Recognizes mouse GITRL.

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