GJA4 (CX37, Connexin-37, connexin 37, gap junction protein, alpha 4, 37kD Connexin 37)

Gap junction alpha-4 protein (GJA4), also called CX37 is a protein that in humans is encoded by the GJA4 gene. This gene is mapped to 1p34.3. This gene encodes a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene have been associated with atherosclerosis and a higher risk of myocardial infarction. CX37 had been shown to reflect the stage and maturity of luteinized follicles in animal studies.\n\nUniProt Number:\nP35212\n\nGene ID:\nGJA4\n\nApplications:\nSuitable for use in Western Blot, Immunohistochemistry (Paraffin) and Immunocytochemistry.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Handling:\nStore at -20?C for one year. After reconstitution, store at 4?C for one month. Can also be aliquoted and stored frozen at -20?C for long term.\nAvoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

144576

Size

100ug

Applications

ICC, IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a lyophilized powder. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Tsai, M.-Y., Lan, K.-C., Huang, K.-E., Huang, F.-J., Kung, F.-T., Chang, S.-Y. Significance of mRNA levels of connexin37, connexin43, and connexin45 in luteinized granulosa cells of controlled hyperstimulated follicles. Fertil. Steril. 80: 1437-1443, 2003.\n2. Wong, C. W., Christen, T., Roth, I., Chadjichristos, C. E., Deroutte, J.-P., Foglia, B. F., Chanson, M., Goodenough, D. A., Kwak, B. R. Connexin37 protects against atherosclerosis by regulating monocyte adhesion. Nature Med. 12: 950-954, 2006.\n3. Yamada, Y., Izawa, H., Ichihara, S., Takatsu, F., Ishihara, H., Hirayama, H., Sone, T., Tanaka, M., Yokota, M. Prediction of the risk of myocardial infarction from polymorphisms in candidate genes. New Eng. J. Med. 347: 1916-1923, 2002.\n

Additional Info

Recognizes human, mouse and rat GJA4. No crossreactivity with other proteins.