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GLDC, NT (GLDC, GCSP, Glycine dehydrogenase [decarboxylating], mitochondrial, Glycine cleavage system P protein, Glycine decarboxylase)

Cat no: 036074

GLDC, NT (GLDC, GCSP, Glycine dehydrogenase [decarboxylating], mitochondrial, Glycine cleavage system P protein, Glycine decarboxylase)

Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).\n\nApplications:\nSuitable for use in Western Blot, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-500\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

036074

Size

200ul

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Form

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

Chang, C.Y., et al. Acta Paediatr Taiwan 49(1):35-37(2008)\nKanno, J., et al. J. Med. Genet. 44 (3), E69 (2007) \nKure, S., et al. Hum. Mutat. 27(4):343-352(2006)

Additional Info

Human, mouse

Alternative Names

GLDC, GCSP, Glycine dehydrogenase [decarboxylating], mitochondrial, Glycine cleavage system P protein, Glycine decarboxylase

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