Gliadin Peptide (14D5) Antibody

Cat no: 250437

Supplier: ABBIOTEC

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Description
Additional Information

Celiac disease is associated with a CD4+ T-cell response to epitopes of gliadin presented by HLA-DQ2 or -DQ8 class II MHC molecules. These epitopes are present in a 33-mer peptide of wheat alpha-gliadin, residues 56-88, which is resistant to digestion and forms a substrate for tissue transglutaminase (TG2), generating the glutamic acid residues essential for binding to HLA-DQ2. The immunogen corresponds to a deamidated form of a region that includes the T-cell epitopes, including the immunodominant PQPQLPY region and two P, Xenopus/Amphibian,PQP motifs associated with binding to IgA from patients with celiac disease. Complete homology e, Xenopus/Amphibian,ists between residues 63-73, 70-80 and 77-87 of wheat alpha gliadin. This antibody reacts strongly with the deamidated peptide but cross-reacts about 5% with the non-deamidated peptide KLQPFPQPQLPYPQPQ

Catalogue number:	250437
Size:	0.2 mg
Accession:	Q41531
Antigen:	Gliadin-related peptide Lys57-Glu65-[alpha-gliadin (58-73)] (KLQPFPQPELPYPQPQ) coupled to immunogenic carrier protein.
Format:	Each vial contains 0.2 mg IgG in 0.2 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography.
P type:	Mouse Monoclonal Antibody
Isotype:	Mouse IgG2a/l
Clonality:	14D5
Additional info:	Alpha gliadin