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Glial Fibrillary Acidic Protein (GFAP)

Glial Fibrillary Acidic Protein (GFAP)

Cat no: G2032-27C

Supplier: United States Biological
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Glial fibrillary acidic protein. Glial fibrillary acidic protein (GFAP) is a class-III intermediate-filament (IF) protein that is highly specific for cells of astroglial lineage, although its tissue-specific role is speculative. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. The gene is localized to chromosome 17q21. Alternate splicing of this gene generates several transcript variants encoding three different isoforms. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (formalin fixed paraffin embedded): 1:50-1:250 Optimal dilutions to be determined by the researcher. Positive Control: Brain Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: G2032-27C
Reactivities: Human, Bovine, Chicken/Bird, Feline, Guinea Pig, Non-Human Primate
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 500ul
Form: Supplied as a liquid, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified
References: 1. Viale et al. Arch A Pathol Anat 418: 339, 1991. 2. Reeves et al. Proc Natl Acad Sci U.S.A. 86: 5178, 1989.
Additional info: Recognizes bovine GFAP. Species Crossreactivity: feline, chicken, guinea pig, hamster, human, monkey.

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