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Glial Fibrillary Acidic Protein (GFAP)

Cat no: G2032-31A


Supplier: United States Biological
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Glial fibrillary acidic protein (GFAP) is a class-III intermediate-filament (IF) protein that is highly specific for cells of astroglial lineage, although its tissue-specific role is speculative. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. The gene encoding the protein GFAP is localized on human chromosome 17q21. Alternate splicing of this gene generates several transcript variants encoding three different isoforms. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:100-1:1000 Immunohistochemistry (paraffin): 1:25-1:50 Immunohistochemistry: Frozen Optimal dilutions to be determined by the researcher. Positive Control: Brain Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: G2032-31A
Reactivities: Human, Mouse, Rabbit
Hosts: Mouse
Applications: Immunohistochemistry, Western Blot
Size: 500ul
Form: Supplied as a liquid, 0.05% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Supernatant
References: 1. Debus et al. Differentiation 25: 193, 1983. 2. Miettinen et al. Ultrastruct Pathol 7: 83, 1984. 3. Royds et al. Acta Neuropathol 70: 320, 1986. 4. Reeves et al. Proc Natl Acad Sci. U.S.A 86: 5178, 1989.
Additional info: Recognizes human GFAP. Species Crossreactivity: mouse and rabbit.

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