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Glucagon, CT (GCG)

Glucagon, CT (GCG)

Cat no: G2040-04C

Supplier: United States Biological
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Glucagon is a member of a multigene family comprising of Secretin, Vasoactive Intestinal Peptide (VIP), Gastric Inhibitory Peptide (GIP) and others like Glicentin and Oxyntomodulin (OXM), which differs from glucagon by C-terminal octapeptide. The glucagon precursor contains at least 3 intervening sequences that divide the protein-coding portion into 4 regions corresponding to the signal peptide and part of the N-terminal peptide, the remainder of the N-terminal peptide and glucagon, glucagon-like peptide-1 (GLP1), and GLP2. The GLP 1 & 2 stimulates intestinal growth and up regulates villus height in the small intestine, concomitant with increased crupt cell proliferation and decreased enterocyte apoptosis. The two GLP's are mainly produced in the A cells of the Islets of Langerhans in response to a drop in blood sugar concentration. Applications: Suitable for use in RIA, Immunohistochemistry and Immunofluorescence. Other applications not tested. Recommended Dilutions: Immunohistochemistry: Frozen and paraffin sections Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: G2040-04C
Reactivities: Human, Mouse, Rat, Porcine
Hosts: Sheep
Applications: Immunofluorescence, Immunohistochemistry
Size: 500ul
Form: Supplied as a liquid in PBS, 0.09% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity chromatography.
References: 1. Huang, Y-H. et al. (2005) Immunohistochemical localization of monoamine oxidase type B in pancreatic islets of the rat. J Histochem Cytochem. 53: 1149-58. 2. Gopel, S.O. et al. (2000) Patch-clamp characterisation of somatostatin-secreting -cells in intact mouse pancreatic islets. J Physiol. 528: 497-507. 3. Huang, Y.H. et al. (2009) Immunohistochemical localization of glucagon and pancreatic polypeptide on rat endocrine pancreas: coexistence in rat islet cells Eur J Histochem. 53: 81-5.
Additional info: Recognizes the C-terminus of porcine Glucagon. Species Crossreactivity: mouse, human and rat

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