Glucagon-like Peptide 1, CT (GLP1)

GLP1, a processed active peptide of 30aa (chr 2q36-q37) is a potent insulin secretagogue, plays a major role in the enteroinsular axis, accounting for the finding that plasma insulin levels accompanying oral intake of glucose are greater than those observed when glucose is given intravenously. The so-called gluco-incretin.\n\nGlucagon is a member of a multigene family comprising of Secretin, Vasoactive Intestinal Peptide (VIP), Gastric Inhibitory Peptide (GIP) and others like Glicentin and Oxyntomodulin (OXM), which differs from glucagon by C-terminal octapeptide. The glucagon precursor contains at least 3 intervening sequences that divide the protein-coding portion into 4 regions corresponding to the signal peptide and part of the N-terminal peptide, the remainder of the N-terminal peptide and glucagon, glucagon-like peptide-1 (GLP1), and GLP2. The GLP 1 & 2 stimulates intestinal growth and up regulates villus height in the small intestine, concomitant with increased crupt cell proliferation and decreased enterocyte apoptosis. The two GLP's are mainly produced in the A cells of the Islets of Langerhans in response to a drop in blood sugar concentration.\n\nApplications:\nSuitable for use in RIA and EIA. Other applications have not been tested.\n\nRecommended Dilution:\nRIA: 1:150,000. Ka = 0.8 x 10e12 L/mole for GLP-1(7

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SPECIFICATIONS

Catalog Number

G2040-36

Size

50ul

Applications

ELISA

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, 0.05% sodium azide, before the addition of 40% glycerol.

P Type

Pab

Purity

Serum

Isotype

IgG

References

1. Uttenthal, L.O., et al., Digestion 54: 395-396 (1993). 2. Van Delft, J., et al., Regul. Pept. 70: 191-198 (1997).

Additional Info

Glucagon-like peptide-1 (7-36) amide (GLP-1), C-terminal reactive. Crossreacts fully with GLP-1 (1-36) amide but shows < 0.1% crossreactivity with the unamidated forms GLP-1 (7-37) and GLP-1(1-37) or other related peptides such as hGLP-2, glucagon, hGIP and VIP. Species Crossreactivity: Most mammalian species. GLP-1 is identical in all mammalian species studied except guinea pig and presumably its South American rodent relatives.