Glucagon-like Peptide 1 Receptor, Mouse, Control Peptide (GLP1R)

Supplier:

United States Biological

Cat no: G2040-38E

Glucagon-like Peptide 1 Receptor, Mouse, Control Peptide (GLP1R)

Glucagon is a member of a multigene family comprising of Secretin, Vasoactive Intestinal Peptide (VIP), Gastric Inhibitory Peptide (GIP) and others like Glicentin and Oxyntomodulin (OXM), which differs from glucagon by C-terminal octapeptide. The glucagon precursor contains at least 3 intervening sequences that divide the protein-coding portion into 4 regions corresponding to the signal peptide and part of the N-terminal peptide, the remainder of the N-terminal peptide and glucagon, glucagon-like peptide-1 (GLP1), and GLP2. The GLP 1 & 2 stimulates intestinal growth and up regulates villus height in the small intestine, concomitant with increased crupt cell proliferation and decreased enterocyte apoptosis. The two GLP's are mainly produced in the A cells of the Islets of Langerhans in response to a drop in blood sugar concentration.\nGLP1 Receptor, a 489aa peptide in mouse, 463aa in rat and human (chr 6p21), it serves as receptor for GLP1. The activity of this receptor is mediated by G protein which activate adenylyl cyclase. GLP1 Receptor is mainly expressed in pancreatic islets, stomach, and lung.\n\nSource:\n17aa peptide of mouse GLP1 Receptor\n\nLocalization:\nMid-region\n\nApplications:\nSuitable for use in ELISA. Other applications not tested..\n\nRecommended Dilutions:\nELISA: 50-100ng of control/ well. Optimal dilutions to be determined by he researcher.\n\nSpecificity:\nRecognizes GLP1R. Species Sequence Homology: human, rat, 100%.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

G2040-38E

Size

50ug

Applications

ELISA

Form

Supplied as a liquid in PBS, pH 7.5.

Purity

Purified

References

1. Flamez, D. et al (1998) Diabetes 47 (4), 646-652; Thorens, B. (1992) PNAS 89 (18), 8641-8645; 2. Suzuki A et al, PNA ( April 2003); 3. Yamamot H et al, J Neurosci (2003)

Additional Info

Recognizes GLP1R. Species Sequence Homology: human, rat, 100%.

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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