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Glucocorticoid Receptor (GCCR, GCR, Glucocorticoid receptor lymphocyte, GR, GRL, Grl1 NR3C1, Nuclear receptor subfamily 3 group C member 1)

Glucocorticoid Receptor (GCCR, GCR, Glucocorticoid receptor lymphocyte, GR, GRL, Grl1 NR3C1, Nuclear receptor subfamily 3 group C member 1)

Cat no: G2040-51A

Supplier: United States Biological
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Cellular Localization: Cytoplasmic in the absence of ligand; nuclear after ligand-binding. Applications: Suitable for use in GS, Western Blot, Immunoprecipitation and Immunocytochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: G2040-51A
Reactivities: Human, Rat
Hosts: Rabbit
Applications: Immunocytochemistry, Immunoprecipitation, Western Blot
Size: 200ul
Form: Supplied as a liquid in PBS, pH 7.2.
P type: Pab
Isotype: IgG
Purity: Serum
Alternative names: GCCR, GCR, Glucocorticoid receptor lymphocyte, GR, GRL, Grl1 NR3C1, Nuclear receptor subfamily 3 group C member 1
References: Roux S et al. Mutation of isoleucine 747 by a threonine alters the ligand responsiveness of the human glucocorticoid receptor. Mol Endocrinol 10:1214-26 (1996). Schuetz JD et al. Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells. Mol Pharmacol 49:63-72 (1996). Srinivasan G et al. Heat shock protein is tightly associated with the recombinant human glucocorticoid receptor:glucocorticoid response element complex. Mol Endocrinol 8:189-96 (1994). Beck CA et al. The steroid antagonist RU486 exerts different effects on the glucocorticoid and progesterone receptors. Endocrinology 133:728-40 (1993). Ashraf J & Thompson EB Identification of the activation-labile gene: a single point mutation in the human glucocorticoid receptor presents as two distinct receptor phenotypes. Mol Endocrinol 7:631-42 (1993).
Additional info: This antibody detects both the unactivated and activated forms of GR. Species Crossreactivity: Crossreacts with Human and Rat.

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