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Glucocorticoid Receptor (GCCR, GCR, GR, GRL, Nuclear Receptor Subfamily 3 Group C Member 1, NR3C1)

Glucocorticoid Receptor (GCCR, GCR, GR, GRL, Nuclear Receptor Subfamily 3 Group C Member 1, NR3C1)

Cat no: G3030-07D

Supplier: United States Biological
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Glucocorticoid receptor is expressed in many cell types and responds to circulating glucocorticoids to mediate cell growth, differentiation or apoptosis. This antibody will help detect glucocorticoid receptor in normal and uncharacterized tissues. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:100-1:250 Immunohistochemistry: 1:10-1:20 for 1 hr at RT Optimal dilutions to be determined by the researcher. Positive Control: Western Blot: MCF7 Immunohistochemistry: Proliferative breast carcinoma (nuclear staining pattern) Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: G3030-07D
Reactivities: Human
Hosts: Mouse
Applications: Immunohistochemistry, Western Blot
Size: 1ml
Form: Supplied as a lyophilized powder in 15mM sodium azide. Reconstitute with 1ml dH2O.
P type: Mab
Isotype: IgG2a
Purity: Supernatant
Alternative names: Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor)
References: 1.Gametchu B, Watson C S and Wu S. Use of receptor antibodies to demonstrate membrane glucocorticoid receptor in cells from human leukemic patients. The FASEB Journal. 7:1283-1292 (1993). 2.Flach H, Kaiser U and Westphal H M. Monoclonal antipeptide antibodies to the glucocorticoid receptor. J. Steroid Biochem. Molec. Biol. 42(5):467-474 (1992). 3.Hollenberg S M, Weingberger C, Ong E S, et al.. Primary structure and expression of a functional human glucocorticoid receptor cDNA. Nature. 318:635-641 (1985). 4.Harmon J M, Eisen H J, Brower S T, et al.. Identification of human leukemic glucocorticoid receptors using affinity labeling and anti-human glucocorti- coid receptor antibodies. Cancer Research. 44:4540-4547 (1984).
Additional info: Recognizes Glucocorticoid Receptor. Species Crossreactivity: Human.

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