Home  >  Products  >  Glucocorticoid Receptor, Phosphorylated (Ser211) (GCCR, GCR, GR, Glucocorticoid Receptor Lymphocyte, GRL, Grl1, Nuclear Receptor Subfamily 3 Group C Member 1, NR3C1)
Glucocorticoid Receptor, Phosphorylated (Ser211) (GCCR, GCR, GR, Glucocorticoid Receptor Lymphocyte, GRL, Grl1, Nuclear Receptor Subfamily 3 Group C Member 1, NR3C1)

Glucocorticoid Receptor, Phosphorylated (Ser211) (GCCR, GCR, GR, Glucocorticoid Receptor Lymphocyte, GRL, Grl1, Nuclear Receptor Subfamily 3 Group C Member 1, NR3C1)

Cat no: G3030-01P

Supplier: United States Biological
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Read More on Supplier Website
The glucocorticoid receptor (GR) belongs to a superfamily of transcription factors that includes receptors for steroid and thyroid hormones, retinoic acid and vitamin D3. GR is normally localized in the cytoplasm, in a non-active state, in a complex with Hsp90 and other factors. On hormone binding, GR changes conformation, is released from the complex, and migrates to the nucleus. Once in the nucleus, the receptor can induce or repress transcription by binding to specific DNA sequences on target genes. The GR has a ubiquitous expression pattern in mammals and is involved in regulation of a number of biological processes through regulation of various target genes. In the mammary gland, it is essential for the differentiation process that leads to lactation. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 0.1-1ug/ml Western Blot: 0.5-2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: G3030-01P
Reactivities: Human
Hosts: Rabbit
Applications: ELISA, Western Blot
Size: 25ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Keeton EK et al (2002) J. Biol. Chem. 277(31), 28247-28255. 2. Roca R et al (2003) Proc. Natl. Acad. Sci. USA. 100(6), 3113-3118. 3. Okret S et al (1984) Proc. Natl. Acad. Sci. USA. 81, 1609-1613.
Additional info: Recognizes human GR, when phosphorylated at Serine 211.

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
Enquiry_down_arrow
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*
See Full Product Listings >
Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave