Glucose Regulated Protein 78 (Hspa5, Heat Shock Protein 5, 78kD, 78kD Glucose-Regulated Protein precursor, AL022860, AU019543, Bip, BiP, D2Wsu141e, D2Wsu17e, Grp78, GRP 78, Heat shock 70kD protein 5, Heat Shock 70kD Protein 5, Hsce70, Immunoglobulin heavy

The immunoglobulin heavy chain binding protein BiP (Binding Protein, [1]) is a member of the hsp70 family of heat shock proteins, and is identical to the glucose regulated protein grp78.2 While BiP was originally described for its function in B cells, it is now known to be distributed in a variety of tissues, if not ubiquitous. The highly conserved hsp 70 proteins have an essential physiological role in stress responses and as

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SPECIFICATIONS

Catalog Number

G3057-20G

Size

500ug

Applications

ELISA, WB

Hosts

Rat

Reactivities

Mouse

Form

Supplied as a liquid in 100mM borate buffered saline, pH 8.0. No preservatives or amine-containing buffer salts added.

P Type

Mab

Purity

Purified

Isotype

IgG1,k

References

1. Bole, D.G., L.M. Hendershot, and J.F. Kearney. 1986. J. Cell Biol. 102:1558. 2. Haas, I.G. 1991. Current Topics Micro. & Immunol. 167:71. 3. Hendrick, J.P. and Hartl, F.U. 1991. FASEB J. 9(15):1559. 4. Pierce, S.K. 1994. Experientia 50(11-12):1026 5. Haas, I.G. 1994. Experientia 50(11-12):1012. 6. Wu, Q. 1996. Southern Biotechnology Associates Inc. (unpublished) 7. Kassenbrock, C.K. and Kelly, R.B. 1989. EMBO J. 8: 233. 8. Hendershot, L. 1996. Personal communication.

Additional Info

Recognizes mouse BiP (Immunoglobulin heavy chain binding protein, Mr 78kD). Recognizes a conserved epitope localized within the region of aa497 to 581 of BiP.