Home  >  Products  >  Glucose Regulated Protein 94 (Grp94, gp96, ECGP, Endoplasmin, Heat Shock Protein 90kD beta Member 1, HSP90b1, Stress Inducible Tumor Rejection Antigen gp96, Tumor Rejection Antigen 1, TRA1)
Glucose Regulated Protein 94 (Grp94, gp96, ECGP, Endoplasmin, Heat Shock Protein 90kD beta Member 1, HSP90b1, Stress Inducible Tumor Rejection Antigen gp96, Tumor Rejection Antigen 1, TRA1)

Glucose Regulated Protein 94 (Grp94, gp96, ECGP, Endoplasmin, Heat Shock Protein 90kD beta Member 1, HSP90b1, Stress Inducible Tumor Rejection Antigen gp96, Tumor Rejection Antigen 1, TRA1)

Cat no: G3057-40J

Supplier: United States Biological
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GRP94 is a 803aa protein belonging to the heat shock protein 90 family. It acts as a molecular chaperone that functions in the processing and transport of secreted proteins. GRP94 and its N-terminal fragment stimulates CTL expansion and maturation of human monocyte-derived dendritic cells (MDDC). It plays a central role in innate as well as acquired immunity, maturation and chemotaxis of dendritic cells, Ab production, cross-priming, as a potential marker in breast cancer and is a peptide acceptor in endoplasmic reticulum and an accessory to peptide loading of MHC class I molecules. Expression of GRP94 suppressed A23187-induced apoptosis and stabilized calcium homeostasis. GRP94 is expressed in melanoma or liver metastases of colon carcinoma cells, human gastric carcinoma BGC-823 cells. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.5-2ug/ml Immunohistochemistry (paraffin): 10ug/ml Optimal dilutions to be determined by the researcher. Positive Control: 3T3 and RAW cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: G3057-40J
Reactivities: Human, Mouse, Non-Human Primate
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity chromatography.
References: 1. Zhang, Y. et al. Biochem. Biophys. Res. Commun. 344:581-587 (2006). 2. Esseghir, S. et al. Clin. Cancer. Res. 13:3164-3173 (2007). 3. Cho, NH. et al. Microbio. Immunol. 48:297-305 (2004).
Additional info: Recognizes human GRP94. Species Crossreactivity: chimpanzee, equine, mouse, monkey. Species sequence homology: rat, bovine, zebrafish, xenopus, chicken.

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