Glucose Regulated Protein 94 (Grp94, gp96, ECGP, Endoplasmin, Heat Shock Protein 90kD beta Member 1, HSP90b1, Stress Inducible Tumor Rejection Antigen gp96, Tumor Rejection Antigen 1, TRA1)

Glucose-regulated proteins are a class of proteins which are synthesized in response to glycose deprivation. These proteins, along with the closely related heat shock proteins may be grouped together as a family of stress-response proteins (srp). Elevated levels of srp have been observed in some cancer cells and may be an indication of the biological stresses that influence tumor growth. In a study of 398 breast cancer patients, high levels of each of the srps predicted a shorter desease-free survival in node-negative patients. High levels of srp were also correlated with high levels of cathepsin D, suggesting srp may also increase the metastatic and invasive potential.\n\nApplications:\nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 0.01-0.03ug/ml\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\n3T3 lysate\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

G3057-40L

Size

100ug

Applications

WB

Hosts

Goat

Reactivities

Mouse

Form

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Stojkovic M, Lako M, Stojkovic P, Stewart R, Przyborski S, Armstrong L, Evans J, Herbert M, Hyslop L, Ahmad S, Murdoch A, Strachan T. Derivation of human embryonic stem cells from day-8 blastocysts recovered after three-step in vitro culture. Stem Cells. 2004;22(5):790-7. PMID: 15342943.

Additional Info

Recognizes mouse TRA1. Species sequence homology: canine and rat.