Glucose Regulated Protein 94 (Grp94, GRP-94, 94kD Glucose Regulated Protein, ECGP, Endoplasmin, gp96, gp96 Homolog, Heat Shock Protein 90kD beta Member 1, HSP90b1, Tumor Rejection Antigen 1, TRA1)

Glucose-regulated proteins are a class of proteins which are synthesized in response to glycose deprivation. These proteins, along with the closely related heat shock proteins may be grouped together as a family of stress-response proteins (srp). Elevated levels of srp have been observed in some cancer cells and may be an indication of the biological stresses that influence tumor growth. In a study of 398 breast cancer patients, high levels of each of the srps predicted a shorter desease-free survival in node-negative patients. High levels of srp were also correlated with high levels of cathepsin D, suggesting srp may also increase the metastatic and invasive potential.\n\nApplications: \nSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nImmunohistochemistry: Frozen\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

G3057-40G

Size

100ug

Applications

IHC, WB

Hosts

Rat

Form

Supplied as a liquid in PBS, 0.05% sodium azide.

P Type

Mab

Purity

Purified

Isotype

IgG2a

References

1. Sorger, P.K. et al. J. Mol. Biol. 194: 341-344 (1987). 2. Tandon, A.K. et.al. Breast Cancer Res. and Treat. 16: 146 (1990).

Additional Info

Recognizes Glucose Regulated Protein 94 at ~94kD.

Alternative Names

94kD Glucose-regulated Protein, Glucose Regulated Protein 94kD, Heat Shock Protein 90kD beta (Grp94) Member 1, Stress Inducible Tumor Rejection Antigen gp96