Home  >  Products  >  GluR1, phosphorylated (Ser849) (Glutamate Receptor 1, GluR-1, AMPA-selective Glutamate Receptor 1, GluR-A, GluR-K1, Glutamate Receptor Ionotropic, AMPA 1, GluA1, GRIA1, GLUH1)
GluR1, phosphorylated (Ser849) (Glutamate Receptor 1, GluR-1, AMPA-selective Glutamate Receptor 1, GluR-A, GluR-K1, Glutamate Receptor Ionotropic, AMPA 1, GluA1, GRIA1, GLUH1)

GluR1, phosphorylated (Ser849) (Glutamate Receptor 1, GluR-1, AMPA-selective Glutamate Receptor 1, GluR-A, GluR-K1, Glutamate Receptor Ionotropic, AMPA 1, GluA1, GRIA1, GLUH1)

Cat no: G3500-04K

Supplier: United States Biological
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Glutamate receptors (GluRs) are the most important mediators of excitatory signal transduction in the central nervous system. They can be pharmacologically classified in three distinct classes: alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, kainate (KA) receptors, and N-methyl-D-aspartate (NMDA) receptors. The AMPA-type glutamate receptor opens in response to glutamate binding, and mediates most of the rapid excitatory postsynaptic current. The activation of AMPA receptors leads to stimulation of a multitude of biochemical pathways in postsynaptic neurones eventually leading to postsynaptic neuronal plasticity. GluR1 belongs to the family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. GluR1 gene is located on human chromosome 5q33 and is expressed granule and pyramidal cells in the hippocampal formation. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Positive Control: Mouse brain tissue Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: G3500-04K
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Lei, S, et al. The Journal of Neuroscience. 20:7932-7940 (2000). 2. Nathalie, S. et al. The Journal of Physiology. 565:381-390 (2005).
Additional info: Recognizes human GluR1, phosphorylated at Ser849. Species Crossreactivity: mouse and rat.

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