GluR2 (Glutamate Receptor)

Cat no: G3500-12C

Supplier: United States Biological

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Glutamate receptor type 2 (GluR2) is one of the four subunits of alpha-amino-5-hydroxy-3-methyl-4-isoxazole propionic acid (AMPA) receptor. AMPA receptor is a non-NMDA-type ionotropic transmembrane receptor for glutamate that mediates fast synaptic transmission in the central nervous system (CNS (1). AMPA receptors are composed of four types of subunits, designated as GluR1, GluR2, GluR3, and GluR4 (alternatively called GluRA-D), which combine to form tetramers (2). The complex comprising of GluR2 and GluR3 is one of the two predominant forms in the adult hippocampus. All four GluRs interact with specific cytoplasmic protein through their C-terminal tails. Although in contrast to GluR1 and GluR4, GluR3 and GluR2 have a short C-terminal tail (3). Applications: Suitable for use in Flow Cytometry, Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000-1:10,000 Flow Cytometry: 1:30 Immunoprecipitation: 1:40 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.

Catalogue number:	G3500-12C
Reactivities:	Human, Mouse, Rat
Hosts:	Rabbit
Applications:	Flow Cytometry, Immunoprecipitation, Western Blot
Size:	100ul
Form:	Supplied as a liquid in 50mM Tris-Glycine, pH 7.4, 0.15M sodium chloride, 0.05% BSA, 0.01% sodium azide, 40% glycerol.
P type:	Mab
Isotype:	IgG
Purity:	Supernatant
References:	1. Pellegrini DE, et al. Proc Natl Acad Sci 88:4157-4161 2001. 2.. Boehm J, et al. Biochem Soc Trans 33:1334-1336. 2005. 3. Dingledine R, et al. Pharm Review 51:7-62. 1999.
Additional info:	Recognizes human GLuR2. Species Crossreactivity: mouse and rat

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GluR2 (Glutamate Receptor)

Cat no: G3500-12C

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