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GLUT3 (Solute Carrier Family 2, Facilitated Glucose Transporter Member 3, Glucose Transporter Type 3, Brain, GLUT-3, SLC2A3)

GLUT3 (Solute Carrier Family 2, Facilitated Glucose Transporter Member 3, Glucose Transporter Type 3, Brain, GLUT-3, SLC2A3)

Cat no: G3900-21A

Supplier: United States Biological
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Most mammalian cells transport glucose through a family of membrane proteins known as glucose transporters. Molecular cloning of these glucose transporters has identified a family of closely related genes that encodes at least 7 proteins (Glut-1 to Glut-13, Mol. Wt. 40-80kD) and Sodium glucose co-transporter-1 (SGLT-1, 662aa; ~75kD). Individual member of this family have identical predicted secondary structures with 12 transmembrane domains. Both N and C-termini are predicted to be cytoplasmic. Most differences in sequence homology exist within the four hydrophilic domains that may play a role in tissue-specific targeting. Glut isoforms differ in their tissue expression, substrate specificity and kinetic characteristics. GLUT3 (human 496aa, mouse 493aa) is the main transporter in neurons, whereas Glut-4 is primarily expressed in muscle and adipose tissue and regulated by insulin. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilutions: Flow Cytometry: ~10ug/ml labels 10e6 cells. Perform the antibody binding in small volume of ~200ul. Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: G3900-21A
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry
Size: 100ug
Form: Supplied as a lyophilized powder from PBS, pH 7.5. Reconstitute with 100ul sterile ddH2O.
P type: Mab
Isotype: IgG2b
Purity: Purified by Protein A/G affinity chromatography.
References: 1. Kayano, T., et al (1988) J. Biol. Chem. 263, 15245-15248. 2. Gould et al., (1992) Diabetologia 35, 304-309. 3. Nagamatsu et al., (1992) J. Biol. Chem. 267, 467-472. 4. Brant et al, (1992) Biochem. Soc. Trans. 20, 235S-236S-403. 5. Baldwin, SA (1993) Biochim. Biophys. Acta 1154, 17-49. 6. Mueckler, M (1994) Eur. J. Biochem. 219, 713-725.
Additional info: Recognizes human Glut-3.

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