Home  >  Products  >  Glutamate Decarboxylase 65 (65kD Glutamic Acid Decarboxylase, GAD 65, GAD65, GAD-65, Glutamate Decarboxylase 2, GAD 2, GAD2, GAD-2, MGC161605, MGC161607)
Glutamate Decarboxylase 65 (65kD Glutamic Acid Decarboxylase, GAD 65, GAD65, GAD-65, Glutamate Decarboxylase 2, GAD 2, GAD2, GAD-2, MGC161605, MGC161607)

Glutamate Decarboxylase 65 (65kD Glutamic Acid Decarboxylase, GAD 65, GAD65, GAD-65, Glutamate Decarboxylase 2, GAD 2, GAD2, GAD-2, MGC161605, MGC161607)

Cat no: G4000-01K

Supplier: United States Biological
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Adults express two forms of glutamate decarboxylase (GAD), GAD65 and GAD67, which are encoded by different independently regulated genes. Both are expressed in most GABA containing neurons. GAD65 appears to be targeted to the membrane and nerve endings; while GAD67 is more widely distributed throughout the cell. GAD65 preferentially synthesizes GABA for vesicular release and GAD67 preferentially synthesizes cytoplasmic GABA. GAD65 is predominantly expressed in pancreatic beta cells and autoantibodies to GAD65 are strongly associated with Insulin-dependent diabetes mellitus (IMDM). Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:10-1:250 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: G4000-01K
Reactivities: Human
Hosts: Rabbit
Applications: ELISA, Western Blot
Size: 1ml
Form: Supplied as a liquid in PBS, 0.09% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by ammonium sulfate precipitation.
Alternative names: EC=4.1.1.15, Glutamate Decarboxylase 65kD Isoform, Glutamate Decarboxylase 2 (Pancreatic Islets and Brain, 65kDa)
Additional info: Recognizes human Glutamate Decarboxylase 65. Species Sequence Homology: bovine, chicken, chimpanzee, canine, equine, mouse, porcine, rat

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