Home  >  Products  >  Glutamate Decarboxylase 65 (GAD65, DCE 2, DCE2, GAD 2, GAD 65 GAD-2, GAD-65, GAD2, Glutamate Decarboxylase 2 (pancreatic islets and brain 65kDa), Glutamate Decarboxylase 2, Glutamic Acid Decarboxylase 2, Glutamic Acid Decarboxylase 65)
Glutamate Decarboxylase 65 (GAD65, DCE 2, DCE2, GAD 2, GAD 65 GAD-2, GAD-65, GAD2, Glutamate Decarboxylase 2 (pancreatic islets and brain 65kDa), Glutamate Decarboxylase 2, Glutamic Acid Decarboxylase 2, Glutamic Acid Decarboxylase 65)

Glutamate Decarboxylase 65 (GAD65, DCE 2, DCE2, GAD 2, GAD 65 GAD-2, GAD-65, GAD2, Glutamate Decarboxylase 2 (pancreatic islets and brain 65kDa), Glutamate Decarboxylase 2, Glutamic Acid Decarboxylase 2, Glutamic Acid Decarboxylase 65)

Cat no: G4000-09

Supplier: United States Biological
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Antibodies to glutamic acid decarboxylase-65 (GAD65) are present in autoimmune disorders such as insulin-dependent (type 1) diabetes mellitus (IDDM), stiff man syndrome and polyendocrine autoimmune disease. Auto-antibodies to GAD65 are present in 60-70% of individuals with newly diagnosed IDDM and thus are important markers for disease activity. These auto-antibodies usually recognize conformation-dependent regions on GAD65 and rarely bind to the second isoform, GAD67. Auto-antibodies to GAD67 are found in only 15% of recent-onset IDDM patients and most of this binding can be blocked with GAD65, suggesting shared epitopes between the two isoforms of GAD. Cellular Localization: Cytoplasmic Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: G4000-09
Reactivities: Human
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in TBS, pH 7.2, 0.5% BSA.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: GAD65, DCE 2, DCE2, GAD 2, GAD 65 GAD-2, GAD-65, GAD2, Glutamate Decarboxylase 2 (pancreatic islets and brain 65kDa), Glutamate Decarboxylase 2, Glutamic Acid Decarboxylase 2, Glutamic Acid Decarboxylase 65
References: Meyre D, et al. Is Glutamate Decarboxylase 2 (GAD2) a genetic link between low birth weight and subsequent development of obesity in children? J Clin Endocrinol Metab. (2005)[Epub ahead of print] PMID: 15671113
Additional info: Species Crossreactivity: Crossreacts with Human. Expected to react with mouse, rat, canine and chimpanzee based on sequence similarity.

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