Home  >  Products  >  Glutamate Decarboxylase 65 (Glutamate Decarboxylase 65 kD Isoform, GAD65, GAD-65, 65 kD Glutamic Acid Decarboxylase, Glutamate Decarboxylase 2, GAD2, MGC161605, MGC161607)
Glutamate Decarboxylase 65 (Glutamate Decarboxylase 65 kD Isoform, GAD65, GAD-65, 65 kD Glutamic Acid Decarboxylase, Glutamate Decarboxylase 2, GAD2, MGC161605, MGC161607)

Glutamate Decarboxylase 65 (Glutamate Decarboxylase 65 kD Isoform, GAD65, GAD-65, 65 kD Glutamic Acid Decarboxylase, Glutamate Decarboxylase 2, GAD2, MGC161605, MGC161607)

Cat no: G4000-01N

Supplier: United States Biological
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GAD65 catalyzes the formation of gamma-aminobutyric acid from L-glutamic acid. It is an autoantigen in type I diabetes and is transiently activated in response to the demand for extra GABA in neurotransmission. It cycles between an active holo form and an inactive apo form. The gene on chromosome 10p12 is a candidate for Human obesity. The cDNA encodes a Mr 65,000 polypeptide, with 585 amino acid residues. The pathogenic role for this enzyme has been identified in the Human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (paraffin): 1:25-1:50 Optimal dilutions to be determined by the researcher. Positive Control: Pancreas Cellular Localization: Cytoplasmic Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: G4000-01N
Reactivities: Rat
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 500ul
Form: Supplied as a liquid in 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Serum
Alternative names: Glutamate Decarboxylase 2 (Pancreatic Islets and Brain, 65kDa), EC=4.1.1.15
References: 1. Bu and Tobin Genomics 21: 222, 1994. 2. Karlsen et al. Proc Natl Acad Sci USA 88: 8337, 1991. 3. Fenalti et al. Nat Struct Mol Biol 14: 280, 2007. 4. Boutin et al. PLoS Biol 1: E68, 2003.
Additional info: Recognizes rat GAD65.

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