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Glutamate Receptor (GPRC1A, GRM1-ALPHA, GRM1A, MGLUR1-ALPHA, MGLUR1A, mGlu1, Glutamate ReceptorMetabotropic 1)

Glutamate Receptor (GPRC1A, GRM1-ALPHA, GRM1A, MGLUR1-ALPHA, MGLUR1A, mGlu1, Glutamate ReceptorMetabotropic 1)

Cat no: G3500-05

Supplier: United States Biological
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L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. The Glutamate Receptor, Metabotropic, 1, (mGluR1 alpha) activates phospholipase C and participates in the central action of glutamate in the central nervous system, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum. Positive Control: Human brain lysate, rat dorsal root ganglion, and rat brain (cingulate cortex) Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: G3500-05
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
Alternative names: GPRC1A, GRM1-ALPHA, GRM1A, MGLUR1-ALPHA, MGLUR1A, mGlu1, Glutamate ReceptorMetabotropic 1
References: 1. Ichise, T., Kano, M., Hashimoto, K., Yanagihara, D., Nakao, K., Shigamoto, R., Katsuki, M. and Alba, A. mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination. Science 288: 1832-1835, 2000. 2. Kim, S. J., Kim, Y. S., Yuan, J. P., Petralia, R. S., Worley, P. F. and Linden, D. J. Activation of the TRPC1 cation channel by metabotropic glutamate receptor mGluR1. Nature 426: 285-291, 2003. 3. Kunishima, N., Shimada, Y., Tsuji, Y., Sato, T., Yamamoto, M., Kumasaka, T., Nakanishi, S., Jingami, H. and Morikawa, K. Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor. Nature 407: 971-977, 2000.

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