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Glutamate Transporter 1b EAAT2b (GLT1b, GLT1v, Slc1a2, Solute Carrier Family 1, Glial High Affinity Glutamate Transporter Member 2)

Glutamate Transporter 1b EAAT2b (GLT1b, GLT1v, Slc1a2, Solute Carrier Family 1, Glial High Affinity Glutamate Transporter Member 2)

Cat no: G4003-91B

Supplier: United States Biological
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GLT1 is the major glial glutamate transporter that takes up more than 90% of glutamate from the synapse. GLT1b is a splice variant that contains 11 unique amino acids at the C-terminus that encode a PDZ binding domain. GLT1b was initially believed to be the neuronal isoform of GLT1, but it now appears that GLT1b is localized to astrocytes in the normal brain and to neurons in pathological conditions. In Lou Gehrig's Disease, GLT1a is decreased, while GLT1b is increased. There are also different expressions in hypoxic cells, which have not yet been fully elucidated. Applications: Suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:200-1:500. A band is seen at ~70kD, representing the GLT1b protein. A band may also be observed at ~50kD. Immunohistochemistry: 1:200-1:500 Immunocytochemistry: 1:200-1:500 Optimal dilutions to be determined by the researcher. Positive Control: Transfected COS7 lysate and rat brain Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: G4003-91B
Reactivities: Mouse, Rat
Hosts: Mouse
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
Size: 100ul
Form: Supplied as a liquid in PBS, pH 7.2. No preservatives added.
P type: Mab
Isotype: IgG2a
Purity: Supernatant
Alternative names: GLT1v, EAAT2b, Glutamate Transporter 1b, Slc1a2, Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 2
References: 1. Lauriat, T.L. & McInnes, L.A., Mol. Psychiatry 12: 1065-1078 (2007). 2. Berger, U.V., et al., J. Comp. Neurol. 492(1): 78-89 (2005). 3. Yi, J.H., et al., Glia 49(1): 121-133 (2005). 4. Pow, D.V., et al., Brain Res. Dev. Brain Res. 153(1): 1-11(2004). 5. Maragakis, N.J., et al., Ann. Neurol. 55(4): 469-77 (2004). 6. Chen, W., et al., J. Neurosci. 22(6): 2142-2152 (2002). 7. Schmitt, A., et al., Neuroscience 109(1): 45-61 (2002).
Additional info: Recognizes rat GLT1b. Does not react with GLT1a. Species Crossreactivity: Mouse. Does not react with human.

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