Home  >  Products  >  Glutamic Acid Decarboxylase 67 (Glutamate Decarboxylase 67 kD Isoform, GAD67, GAD-67, 67 kD Glutamic Acid Decarboxylase, GAD, Glutamate Decarboxylase 1, GAD1, FLJ45882, SCP)
Glutamic Acid Decarboxylase 67 (Glutamate Decarboxylase 67 kD Isoform, GAD67, GAD-67, 67 kD Glutamic Acid Decarboxylase, GAD, Glutamate Decarboxylase 1, GAD1, FLJ45882, SCP)

Glutamic Acid Decarboxylase 67 (Glutamate Decarboxylase 67 kD Isoform, GAD67, GAD-67, 67 kD Glutamic Acid Decarboxylase, GAD, Glutamate Decarboxylase 1, GAD1, FLJ45882, SCP)

Cat no: G4000-12K

Supplier: United States Biological
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Glutamate Decarboxylase (EC 4.1.1.15) catalyzes the conversion of L-glutamic acid to GABA, a major inhibitory neurotransmitter in the CNS. GAD67, a 67kD protein, is a neuronal isoform of this enzyme predominantly expressed in human Brain. It consists of Pyridoxal 5'-phosphate binding site and conserved Cysteine residues which are vital for its activity and is inhibited due to phosphorylation. It has high binding affinity for the cofactor Pyridoxal-5'phosphate and its role has been implicated in normal Palate development. It is found to be associated with childhood onset schizophrenia and craniofacial malformations and has been identified as a major auto antigen and an auto-reactive T-cell target in IDDM. Deficiency of this enzyme leads to pyridoxine dependency along with epilepsy. It also might play a role in stiff main syndrome. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5ug/ml Optimal dilutions to be determined by the researcher. Positive Control: SK-N-SH Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: G4000-12K
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity Chromatography.
Alternative names: Glutamate Decarboxylase 1 (Brain, 67kDa), EC=4.1.1.15
References: 1. Asada et.al PNAS 94: 6496-6499 (1997) 2. Wei et.al J Neurochem., 93(3):624-33 (2005 May) 3. Addington et.al Mol Psychiatry., 10(6):581-8 (2005 Jun) 4. Steven et.al J Biol Chem, 275 (7); 5188-5192 (February 18, 2000).
Additional info: Recognizes human GAD67. Species sequence homology: mouse and rat.

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