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Glutaredoxin-1 (GLRX, GRX, GRX1, MGC117407, Thioltransferase-1, TTase-1)

Glutaredoxin-1 (GLRX, GRX, GRX1, MGC117407, Thioltransferase-1, TTase-1)

Cat no: G7210-01

Supplier: United States Biological
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Glutaredoxin (Grx), also known as thiol transferase, is a small heat stable oxidoreductase. Glutaredoxins form part of the glutaredoxin system, comprising NADPH, GSH and glutathione reductase, which transfers electrons from NADPH to glutaredoxins via GSH. First recovered in E.coli as GSH dependent hydrogen donors for ribonucleotide reductase, Glutaredoxin catalyzes GSH disulfide oxido reductase via two redox active cysteine residues. The active sequence (Cys-Pro-Tyr-Cys) is conserved in a variety of species. The 12kD dithiol protein has a role in reduction of mixed disulfides in cells exposed to oxidative stress. Applications: Suitable for use in ELISA, Immunohistochemistry (paraffin), and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: G7210-01
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2.
P type: Mab
Isotype: IgG2a,k
Purity: Purified.
References: 1.S-glutathionylation of IRF3 regulates IRF3-CBP interaction and activation of the IFNbeta pathway. Prinarakis E, Chantzoura E, Thanos D, Spyrou G.EMBO J. 2008 Mar 19;27(6):865-75. Epub 2008 Feb 28.
Additional info: Recognizes human GLRX.

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