Human glutathione peroxidase 1 (GPX1), a 22kD ubiquitously expressed selenium-dependent antioxidant enzyme and member of the glutathione peroxidase family, which catalyzes the glutathione-mediated reduction of toxic peroxides, protecting against oxidative damage and free radicals. Genetic polymorphisms resulting in variants of GPX1 have been linked with various cancers, including lung cancer, bladder cancer, and a significantly increased risk of developing breast cancer.
Applications:
Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilution:
ELISA: 1:32,000
Western Blot: 1-3 ug/ml. detects a band of approximately 22kD in human liver and kidney cell lysates.
Storage and Stability:
May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add 40-50% glycerol, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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