Glutathione Peroxidase 4 (GPX4 (phospholipid hydroperoxidase)GPX-4, MCSP, PHGPx, Phospholipid hydroperoxide glutathione peroxidase, mitochondrial, snGPx, snPHGPx)

Glutathione Peroxidase 4 (GPX4; also known as PHGPx) is a monomeric, 21kD member \nof the glutathione peroxidase family of proteins. It is widely expressed and serves to both \nprotect cell membranes from phospholipid and cholesterol hydroperoxidases, and form an \ninactive enzyme structural component of the sperm mitochondrial capsule. Human GPX4 is \n197 amino acids (aa) in length and contains a mitochondrial targeting sequence (aa 1-27) \nand an enzymatically active selenocysteine at Sec73. During sperm maturation, the \ntargeting sequence is cleaved, and GPX4 may form inactive covalently-linked oligomers. \nThere are multiple splice variants. One is ubiquitously expressed, cytoplasmic, and shows \nan alternate start site at Met28. A second is 226 aa in length, nuclear, and shows an \nArg-rich 65 aa substitution for aa 1-28. Over amino acids 74-168, human GPX4 shares \n93% aa identity with mouse GPX4. \n\nApplications:\nSuitable for Western Blot. Other applications not tested.\n\nStorage:\nLyophilized samples are stable for twelve months from date of receipt when stored at -20 degrees C to -70 degrees C. Upon reconstitution, the antibody can be stored at 2 degrees -8 degrees C for 1 month without detectable loss of activity. Reconstituted antibody can also be aliquotted and stored frozen at -20 degrees C to -70 degrees C in a manual defrost freezer for six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts