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Glutathione Reductase (Glutathione Reductase, Mitochondrial, GR, GRase, GSR, GLUR, GRD1)

Glutathione Reductase (Glutathione Reductase, Mitochondrial, GR, GRase, GSR, GLUR, GRD1)

Cat no: G8127-19D

Supplier: United States Biological
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Glutathione reductase (GSR or GR) is a crucial flavoenzyme in the antioxidant defense system that maintains high levels of reduced glutathione in the cytosol. It belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family and is a flavoprotein homodimer of two equal subunits with one mole of noncovalently bound FAD in each subunit. GR reduces glutathione disulphide (GSSG) to the sulfhydryl form (GSH) which is an important cellular oxidant and is used by glutathione peroxidase to detoxify hydrogen peroxide. Apart from NADPH, GR also uses FAD as a cofactor for the process. In sperm, GR and glutathione peroxidase function as antioxidant enzymes and thus may inhibit lipid peroxidation. GR is stimulated by melatonin and is reportedly irreversibly inhibited by a number of oxygen radical generating systems. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-1ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human Liver lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: G8127-19D
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein A affinity chromatography.
References: 1. Lenzi, A. et al. Hum. Reprod. 9:2044-2050 (1994). 2. Reiter, RJ. et al. Ann. N.Y. Acad. Sci. 854:410-424 (1998). 3. Wan, WY. et al. J. Mol. Biol. 286:1633-1649 (1999).
Additional info: Recognizes s. cerevisiae GR. Species Crossreactivity: human.

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