Glutathione S Transferase, pi (GSTP1, GSTpi1, GST3, DFN7)

Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other dise.\n\nApplications:\nSuitable for use in ELISA and Western Blot. Other applications have not been tested. \n\nRecommended Dilutions: \nPeptide ELISA Titer: 1:32,000\nWestern Blot: 0.01-0.03ug/ml detects ~24kD band observed in Human Kidney, Liver and Lung lysates (calculated MW of 23.4kD according to NP_000843.1). In transfected HEK293 transiently expressing GSTP1 band of approx. 26kD is observed. This band is not observed in the non-transfected HEK293.\nOptimal dilutions to be determined by the researcher. \n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

G8135-25G

Size

100ug

Applications

ELISA, WB

Hosts

Goat

Reactivities

Hum

Form

Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.

P Type

Pab

Purity

Purified by peptide affinity chromatography.

Isotype

IgG

References

1.Malerba G, Pignatti PF. A review of asthma genetics: gene expression studies and recent candidates.\nJ Appl Genet. 2005;46(1):93-104. Review.

Additional Info

Recognizes human GSTP1. Species sequence homology: mouse, rat, canine, bovine.

Alternative Names

glutathione S-transferase pi 1, glutathione transferase, fatty acid ethyl ester synthase III, deafness, X-linked 7, PI, FAEES3, DFN7, HGNC:4638, glutathione S-transferase pi, GST3, GSTP1