Home  >  Products  >  Glycine Receptor, alpha1 (Glycine Receptor alpha 1, Glycine Receptor Subunit alpha-1, Glra1, Glycine Receptor 48 kD Subunit, Glycine Receptor Strychnine-binding Subunit, Glyr, [a]Z1)
Glycine Receptor, alpha1 (Glycine Receptor alpha 1, Glycine Receptor Subunit alpha-1, Glra1, Glycine Receptor 48 kD Subunit, Glycine Receptor Strychnine-binding Subunit, Glyr, [a]Z1)

Glycine Receptor, alpha1 (Glycine Receptor alpha 1, Glycine Receptor Subunit alpha-1, Glra1, Glycine Receptor 48 kD Subunit, Glycine Receptor Strychnine-binding Subunit, Glyr, [a]Z1)

Cat no: G8167-01A

Supplier: United States Biological
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Glycine is an important inhibitory transmitter in the brainstem and spinal cord. Glycine receptors are members of the ligand-gated ion channel family (LGICs) that mediate rapid chemical neurotransmission. The binding of glycine to its receptor produces a large increase in chloride conductance, which causes membrane hyperpolarization. Glycine receptors are anchored at inhibitory chemical synapses by a cytoplasmic protein, gephyrin. Gene targeting in mice showed that gephyrin is required for synaptic clustering of glycine receptors in spinal cord. The glycine receptor has been as a model system for identifying binding sites for alcohol on the LGIC family of proteins. These receptors have also been extremely useful in studies of synaptic clustering of receptors. During postnatal motoneuron development, the glycine receptor a-subunit changes from a2 (fetal) to a1 (adult). Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (frozen): 1:1000 Western Blot: 1:1000-2000 Optimal dilutions to be determined by the researcher. Positive Control: Rat brain stem or spinal cord Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile ddH2O or PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: G8167-01A
Reactivities: Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 50ul
Form: Supplied as a lyophilized powder in 5mM ammonium bicarbonate.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Lynch JW. 2004. Molecular structure and function of the glycine receptor chloride channel. Physiol Rev.84:1051-1095. 2. Colquhoun D, Sivilotti LG. 2004. Function and structure in glycine receptors and some of their relatives. Trends Neurosci. 27:337-344. 3. Cascio M. 2004.Structure and function of the glycine receptor and related nicotinicoid receptors. J Biol Chem. 7:19383-19386.
Additional info: Recognizes rat Glycine Receptor.

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