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Glycogen Synthase Kinase 3 beta, phosphorylated (Ser9) (Glycogen Synthase Kinase-3 beta, GSK-3 beta, GSK3b)

Glycogen Synthase Kinase 3 beta, phosphorylated (Ser9) (Glycogen Synthase Kinase-3 beta, GSK-3 beta, GSK3b)

Cat no: G8170-53T

Supplier: United States Biological
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Glycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that is involved in the regulation of many signaling pathways. To date, 2 isoforms have been identified: GSK3a and GSK3b. Specifically, GSK3b has been shown to play a key inhibitory role in both the insulin and Wnt signaling pathways (Papkoff and Aikawa 1998). It has been suggested that Ser9 phosphorylation underlies the inhibition of GSK3 by insulin (Sutherland et al., 1993). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Positive Control: Rat cortex lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: G8170-53T
Reactivities: Human, Mouse, Bovine, Chicken/Bird
Hosts: Rabbit
Applications: Western Blot
Size: 100ul
Form: Supplied as a liquid in 1 mM HEPES, pH 7.5, 150mM sodium chloride, 100ug per ml BSA, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: EC=2.7.11.26
References: 1. Sutherland C, Leighton IA, Cohen P (1993) Inactivation of glycogen synthase kinase 3 beta by phosphorylation: new kinase connections in insulin and growth factor signaling. Biochem J. Nov 15;296 (Pt. 1):15-9. 2. Papkoff J, Aikawa M (1998) WNT-1 and HGF regulate GSK3b activity and beta catenin signaling in mammary epithelial cells. Biochem Biophys Res Commun. Jun 29;247(3):851-8.
Additional info: Recognizes human Glycogen Synthase Kinase 3, phosphorylated at (Ser9). Species Crossreactivity: bovine, chicken and mouse.

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