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Glycogen Synthase, phosphorylated (Ser640)

Glycogen Synthase, phosphorylated (Ser640)

Cat no: G8170-18E

Supplier: United States Biological
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Human muscle glycogen synthase (GS) is responsible for the biosynthesis of glycogen from phosphorylated glucose units. Mammalian liver and muscle contain GS consisting of four subunits with a total molecular weight of 360,000. GS is subject to regulation through both allosteric and covalent modification and occurs in two forms: the phosphorylated inactive form, and the dephosphorylated active form. GS is inactivated by the serine/threonine kinase called glycogen synthase kinase-3b that mainly functions to phosphorylate muscle glycogen synthase. This antibody is specific for the phosphorylated form of GS at Ser 640. Phosphorylation of GS at S640 has been associated with Antiphospholipid Antibody Syndrome. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: G8170-18E
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: ELISA, Western Blot
Size: 50ug
Form: 0.02 M Potassium Phosphate with 0.15 M Sodium Chloride containing 0.01% Sodium Azide [pH 7.2]
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: DiGiovanna MP et al. Production of Polyclonal anti-Phosphopeptide Antibodies. Curr. Prot. Immunol. 11:6.1-6.19 (1996).
Additional info: This phospho specific polyclonal antibody is specific for phosphorylated Ser 640 of human muscle glycogen synthase. Reactivity with non-phosphorylated human muscle glycogen synthase is less than 1% by ELISA. Species Crossreactivity: Crossreacts with Human and Mouse.

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