Glycophorin A (Glycophorin-A, MN Sialoglycoprotein, PAS-2, Sialoglycoprotein alpha, CD235a, GYPA, GYPA)

Four main species of sialic acid-rich glycoproteins known as glycophorins A, B, C, and D have been characterized on human erythrocytes. These components carry blood group determinants and various receptors for lectins, bacteria, viruses, and parasites. Glycophorin A (GYPA) is a major sialoglycoprotein of the human erythrocyte membrane. It carries several medically important blood group antigens, M or N blood group antigen, which is determined byaa at residues 1 and 5. Glycophorin A spans the membrane with its amino terminus on the outside and its carboxyl terminus in the cytoplasm and has a molecular weight of 31kD The protein is specifically expressed on erythroid cell lineage. The gene encoding the glycophorin A protein maps to 4q28.2-q31.1 region of human chromosome and consists of 7 exons and has 97% sequence homology with glycophorin B.\n\nApplications:\nSuitable for use in Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nImmunohistochemistry (paraffin): 1:25-1:50\nImmunohistochemistry: Frozen\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nTonsil\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

G8177-10A

Size

500ul

Applications

IHC

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid, 0.05% sodium azide.

P Type

Mab

Purity

Supernatant

Isotype

IgG1

References

1. Erber et al. Hematol Rev %: 113, 1991. 2. Greaves et al. Blood 61: 645, 1983. 3. Loken et al. Blood 69: 255, 1987 4. Kudo et al. Proc Natl Acad Sci U.S.A. 86: 4619, 1989.

Additional Info

Recognizes human Glycophorin A.