Four main species of sialic acid-rich glycoproteins known as glycophorins A, B, C, and D have been characterized on human erythrocytes. These components carry blood group determinants and various receptors for lectins, bacteria, viruses, and parasites. Glycophorin A (GYPA) is a major sialoglycoprotein of the human erythrocyte membrane. It carries several medically important blood group antigens, M or N blood group antigen, which is determined byaa at residues 1 and 5. Glycophorin A spans the membrane with its amino terminus on the outside and its carboxyl terminus in the cytoplasm and has a molecular weight of 31kD The protein is specifically expressed on erythroid cell lineage. The gene encoding the glycophorin A protein maps to 4q28.2-q31.1 region of human chromosome and consists of 7 exons and has 97% sequence homology with glycophorin B.
Applications:
Suitable for use in Immunohistochemistry. Other applications not tested.
Recommended Dilution:
Immunohistochemistry (paraffin): 1:25-1:50
Immunohistochemistry: Frozen
Optimal dilutions to be determined by the researcher.
Positive Control:
Tonsil
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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