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Glycophorin A (Glycophorin-A, MN Sialoglycoprotein, PAS-2, Sialoglycoprotein alpha, CD235a, GYPA, GYPA)

Glycophorin A (Glycophorin-A, MN Sialoglycoprotein, PAS-2, Sialoglycoprotein alpha, CD235a, GYPA, GYPA)

Cat no: G8177-12G

Supplier: United States Biological
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Four main species of sialic acid-rich glycoproteins known as glycophorins A, B, C, and D have been characterized on human erythrocytes. These components carry blood group determinants and various receptors for lectins, bacteria, viruses, and parasites. Glycophorin A (GYPA) is a major sialoglycoprotein of the human erythrocyte membrane. It carries several medically important blood group antigens, M or N blood group antigen, which is determined byaa at residues 1 and 5. Glycophorin A spans the membrane with its amino terminus on the outside and its carboxyl terminus in the cytoplasm and has a molecular weight of 31kD The protein is specifically expressed on erythroid cell lineage. The gene encoding the glycophorin A protein maps to 4q28.2-q31.1 region of human chromosome and consists of 7 exons and has 97% sequence homology with glycophorin B. Applications: Suitable for use in Immunohistochemistry and Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1-3ug/ml Immunohistochemistry (paraffin): 2-4ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human Liver lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: G8177-12G
Reactivities: Human
Hosts: Goat
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Tolia NH, Enemark EJ, Sim BK, Joshua-Tor L. Structural Basis for the EBA-175 Erythrocyte Invasion Pathway of the Malaria Parasite Plasmodium falciparum. Cell. 2005 Jul 29;122(2):183-93. PMID: 16051144.
Additional info: Recognizes human Glycophorin A.

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