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Glypican 4, aa509-520 (K-glypican, UNQ474/PRO937, GPC4)

Glypican 4, aa509-520 (K-glypican, UNQ474/PRO937, GPC4)

Cat no: G8235-52E

Supplier: United States Biological
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Glypican-4, previously known as K-glypican, is a GPI-linked cell surface heparan sulfate proteoglycan of the glypican gene family, that comprises 6 members at present. Its function is only partially understood at present. However, glypican-4 seems to be involved in the control of cell growth and diffe-rentiation, especially in the development of the central nervous system and the kidney. Furthermore, glypican-4 is expressed by haematopoetic stem cells and bone marrow stromal cells. Although the antiserum was prepared against a peptide from hu man glypican-4, due to the highly conserved structure and se-quence of glypican-4, antiserum anti-peptide 1 (aa88-101) was used successfully to study brain development in the mouse. Applications: Suitable for use in ELISA, Western Blotting, Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blotting: 1:1000-1:2000 Immunohistochemistry: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at 4 degrees C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: G8235-52E
Reactivities: Human
Hosts: Rabbit
Applications: ELISA, Immunohistochemistry, Western Blot
Size: 20ul
Form: Supplied as a lyophilized powder in PBS, pH 7.2. Reconstitute in ddH2O.
P type: Pab
Purity: Serum
References: 1. Siebertz B, Drzeniek Z, Sto?cker G, Just U, Handt S, Haubeck HD (1999): Expression of glypican-4 in haematopoietic progenitor and bone marrow stromal cells. Biochem J 344: 937-43 2. Ford-Perriss M, Turner K, Guimond S, Apedaile A, Haubeck HD, Turnbull J, Murphy M (2003): Localisation of specific heparan sulfate proteoglycans during the proliferative phase of brain development. Dev Dyn 227: 170-184
Additional info: Specific for a core protein epitope (aa 509-520) of human glypican- 4.

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