GM1489

Supplier:

United States Biological

Cat no: G8236

GM1489

GM1489, an analog of GM 6001, acetohydroxamic acid, is a potent broad spectrum inhibitor of matrix metalloproteinases (MMPs). Also reduces the inflammatory and the hyperproliferative responses that occur following topical phorbol ester application.\n\nNomenclature: N-[(2R)-2-(Carboxymethyl)-4-methylpentanoyl]-L-tryptophan-(S)-methylbenzylamide\n\nReported Ki values are as follows: \nKi = 0.2nM for interstitial collagenase (MMP-1)\nKi = 500nM for gelatinase A (MMP-2)\nKi = 20uM for stromelysin (MMP-3)\nKi = 100nM for neutrophil collagenase (MMP-8)\nKi = 100nM for gelatinase B (MMP-9)]. \n\nApplications: Suitable for use in Cell Culture.\n\nRecommended Dilutions:\nCell Culture: 10-25uM (1mg/ml in DMSO = 2.57mM)\n\nRecommended Dilution Buffer: \n50mM Tris pH7.5, 150mM NaCl, 20mM CaCl2-2H2O.\n\nPurity: (same/more than) 98% by HPLC\nAppearance: White to off-white powder\nMelting Point: 181-182C\n\nConcentration: It is recommended that the concentration of GM6001 in aqueous working solutions is determined upon dilution and confirmed prior to each use. Relative concentrations of GM6001 in aqueous solutions may be determined by measuring the absorbance of the solution (tyrosine) at 280 nm.\n\nReconstitution: Reconstitute in DMSO (400mg/ml). Other organic solvents (ethanol) have also been used. G8237 will precipitate from aqueous solutions exceeding 100uM. Aqueous dilutions should be performed using low salt buffers to prevent precipitation from solution.\n\nQuality Control:\nH-NMR Spectrum: Conforms\nMass Spectrum: 389 [M+1]\nThin Layer Chromatography (ethylacetate:methanol = 6:1): Single spot\n\nStorage and Stability:\n-20 degrees C. Protect from moisture. Following reconstitution aliquot and freeze (-20 degrees C). This product is stable for 2 years as supplied. Stock solutions are stable for up to 6 months at -20 degrees C.

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SPECIFICATIONS

Catalog Number

G8236

Size

1mg

References

1. Holleran, W.M., et al. 1997. Arch. Dermatol. Res. 289, 138. 2. Matrix metalloproteinase inhibitors reduce phorbol ester-induced cutaneous inflammation and hyperplasia, Holleran WM, Galardy RE, Gao WN, Levy D, Tang PC, Elias PM., Department of Dermatology, School of Medicine, University of California San Francisco. 3. Infection and Immunity, Nov. 2005, p. 7548

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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