GO? 6976 (5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile, Go6976, PD 406976)

Cat no: G8490

Supplier: United States Biological

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Cell-permeable. A potent protein kinase C (PKC) inhibitor (IC50 = 7.9nM). In vitro, discriminates between Ca2+- dependent and -independent isoforms of PKC; selectively inhibits PKC alpha and PKC beta1 (IC50 values are 2.3 and 6.2 nM respectively) but does not inhibit the activity of PKCd, -E, or -Z (IC50 > 3microM). Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Catalogue number:	G8490
Size:	500ug
Form:	Supplied as an off-white to yellow solid. Reconstitute with DMSO.
Purity:	~99% (HPLC).
Alternative names:	5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]py-rrolo[3,4-c]carbazole-12-propanenitrile; Go6976; PD 406976
References:	1. Kleinschroth, J., et al. (1993). Bioorg. Med. Chem. 3, 1959- 1964; Martiny-Baron, G.,et al. (1993). J. Biol. Chem. 268, 9194-9197.

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GO? 6976 (5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile, Go6976, PD 406976)

Cat no: G8490

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