Goat anti Bovine IL2 polyclonal antibody

Goat Anti-Bovine IL2 polyclonal antibody for ELISA(Cap), ICC/IF, WB. Bovine Interleukin-2 (IL-2) is a 15 kDa, alpha-helical, single chain, potentially glycosylated polypeptide that has potent stimulatory activity for antigen-activated T cells. The molecule is synthesized as a 155 amino acid (aa) precursor that contains a 20 aa signal peptide plus a 135 aa mature segment that is possibly O-glycosylated. The mature region has multiple alpha-helices and one intrachain disulfide bond. Mature bovine IL-2 is 64%, 60%, 49%, 50%, 72%, 63% and 67% to mature human, canine, mouse, rat, porcine, equine, and feline IL-2, respectively. Mammalian cells known to express IL-2 include CD4+ and CD8+ T cells, visceral smooth muscle cells, eosinophils, gamma d T cells, B cells and dendritic cells. The receptor for IL-2 is complex and consists of three distinct subunits in varying combinations. Two of these are ligand-binding and are termed IL-2 R alpha and IL-2 R beta. IL-2 R alpha is 55 kDa and binds IL-2 with low affinity. IL-2 R beta bis 75 kDa and binds IL-2 with intermediate affinity. Signal transduction is performed by both IL-2 R beta b and a 64 kDa common gamma chain (gamma c). This signal transducing common gamma chain does not bind IL-2, but does heterodimerize with IL-2 R beta b to form a functional IL-2 receptor. The complex heterotrimeric alpha-beta-gamma c receptor may arise from IL-2 binding to preformed R alpha-R beta b complexes. Functionally, IL-2 is best known for its autocrine and paracrine activity on T cells. It drives resting T cells into active G1, inducing IL-2 and IL-2 R alpha synthesis and cell proliferation. It also promotes Fas-induced death of naГЇve CD4+ T cells, while having minimal effect on activated CD4+ memory lymphocytes. Finally, IL-2 seems to play a central role in the expansion and maintenance of CD4+ CD25+ regulatory T cells. Thus, IL-2 may be a key cytokine in the natural suppression of autoimmunity.

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SPECIFICATIONS

Catalog Number

CABT-L113

Hosts

Goat

Reactivities

Bov

Conjugates

Unconj

Target

IL2

Gene Id

280822

Isotype

IgG

Clonality

Polyclonal

Storage Temp

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 В°C as supplied. 1 month, 2 to 8 В°C under sterile conditions after reconstitution. 6 months, -20 to -70 В°C under sterile conditions after reconstitution.