Goat Anti-Human DPYSL2 (C-terminal) polyclonal antibody for ELISA, IHC, WB. Collapsin response mediator protein-2 (CRMP-2) is an important brain-specific protein whose expression is restricted to the developing nervous system, especially in the distal portions of growing axons. It can promote the formation of axons by its ability to bind to tubulin heterodimers and enhance microtubule polymerization. CRMP-2 is known to exist as a dimer and dimerazation may be necessary for its activity. Although CRMP-2`s role in development has been extensively studied, its role in the adult and diseased brain is less well understood. Since CRMP-2 is present in adult and aged brains, there is reason to speculate that it may have a role in neuritic and axonal growth and regeneration and thus contribute to a high level of plasticity in adult brains. In some disease states, CRMP-2 has been shown to be reduced, such as in Down syndrome fetal brain, epilepsy brain hippocampus and areas of traumatic brain injury. In Alzheimer`s disease, CRMP-2 has been shown to be associated with the paired helical filaments (PHF) in degenerating neurons. This PHF-associated CMPR-2 has been shown to be highly phosphorylated. This hyperphosphorylated form of CMPR-2 may lead to its inactivation and may accelerate the neuritic degeneration in Alzheimer`s disease.
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