Goat anti Human Heparin Cofactor II polyclonal antibody [HRP]

Cat no: CABT-L493

Supplier: Creative Diagnostics

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Goat Anti-Human Heparin Cofactor II polyclonal antibody for IEP, ELISA. Heparin Cofactor II (HCII), also known as heparin cofactor A and dermatan sulphate cofactor, is a single chain glycoprotein produced in the liver and circulates in plasma at concentration of 50-100 ?g/ml (0.8-1.5 ?M). A member of the SERPIN family of proteinase inhibitors, HCII exhibits a relatively narrow specificity and is only known to inhibit the serine proteinases thrombin and chymotrypsin. The inhibitory activity toward thrombin is accelerated up to 1000-fold in the presence of optimal concentrations of heparin. Unlike Antithrombin, thrombin inhibition by HCII is also enhanced by dermatan sulphate. HCII has an apparent molecular weight of 65,600 daltons and interaction with thrombin results in a covalent 1:1 enzyme-inhibitor complex of 102,600 daltons.

Catalogue number:	CABT-L493
Reactivities:	Human
Hosts:	Goat
Applications:	ELISA
Gene:	3053
Target:	SERPIND1
Isotype:	IgG
Clonality:	Polyclonal
Storage temp:	Store between -10 and -20°C. Product will become viscous but will not freeze. Avoid storage in frost-free freezers. Keep vial tightly capped. Allow product to warm to room temperature and gently mix before use. Avoid exposure to sodium azide as this is an inhibitor of peroxidase activity.

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Goat anti Human Heparin Cofactor II polyclonal antibody [HRP]

Cat no: CABT-L493

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