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Goat anti Human TREM1 polyclonal antibody

Goat anti Human TREM1 polyclonal antibody

Cat no: CABT-L245

Supplier: Creative Diagnostics
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Goat Anti-Human TREM1 polyclonal antibody for ELISA(Cap), FC, Func, WB. TREM-1 (Triggering Receptor Expressed on Myeloid cells) is a type I transmembrane protein having a single Ig-like domain. It associates with the adapter protein, DAP12, to deliver an activating signal. Several other TREM family members have been reported that are structurally similar but share less than 30% amino acid identity. TREM-1 is expressed on blood neutrophils and a subset of monocytes, and expression is up-regulated by bacterial LPS. The natural ligand for TREM-1 has not been identified. However, engagement of TREM-1 with an agonist monoclonal antibody leads to expression of IL-8, MCP-1, and TNF-alpha, suggesting that this receptor plays an important role in inflammatory responses. TREM-1 is expressed at high levels on neutrophils of patients with microbial sepsis and in mice withLPS-induced shock. Blockade of TREM-1 with a TREM-1/Fc fusion protein protected mice against LPS-induced shock. Human and mouse TREM-1 share approximately 42% amino acid sequence homology.
Catalogue number: CABT-L245
Reactivities: Human
Hosts: Goat
Conjugates: Unconjugated
Gene: 54210
Target: TREM1
Isotype: IgG
Clonality: Polyclonal
Storage temp: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

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