Goat anti Mouse C5 polyclonal antibody [Biotin]

Goat Anti-Mouse C5 antibody for ELISA(Det), WB. Mouse Complement 5a (C5a) is an enzymatically generated glycoprotein that belongs to a family of structurally and functionally related proteins known as Anaphylatoxins. C5a is a 77 amino acid (aa) peptide that is created by the activity of C5a convertase on the C5 alpha-chain. Mouse C5a has four alpha-helices, plus three intrachain disulfide bonds that create a triple loop structure. In serum, proteolytic processing removes the C-terminal arginine, creating a low activity C5a desArg77 molecule. Mouse C5a shares 60% and 82% aa sequence identity to human and rat C5a, respectively. C5a binds to a signaling G-protein coupled receptor (GPCR) (C5aR/CD88), inducing neutrophil chemotaxis and endothelial cell activation. It also triggers an oxidative burst in macrophages and neutrophils, and induces release of histamine in basophils and mast cells. Alternatively, it may also bind to a nonsignaling GPCR termed C5L2 whose function is yet to be determined.

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SPECIFICATIONS

Catalog Number

CABT-L278

Hosts

Goat

Reactivities

Mouse

Conjugates

Biotin

Target

C5

Gene Id

15139

Isotype

IgG

Clonality

Polyclonal

Storage Temp

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 В°C as supplied. 1 month, 2 to 8 В°C under sterile conditions after reconstitution. 6 months, -20 to -70 В°C under sterile conditions after reconstitution.