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Goat anti Mouse IFNGR1 polyclonal antibody [Biotin]

Goat anti Mouse IFNGR1 polyclonal antibody [Biotin]

Cat no: CABT-L301

Supplier: Creative Diagnostics
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Goat Anti-Mouse IFNGR1 polyclonal antibody for ELISA(Det). The high-affinity IFN-gamma receptor complex is made up of two type I membrane proteins, IFN-gamma R1 (IFN-gamma R alpha) and IFN-gamma R2 (IFN-gamma R beta b). Both proteins are members of the type II cytokine receptor family and share approximately 52% overall sequence identity. IFN-gamma R1 is the ligand-binding subunit that is necessary and sufficient for IFN-gamma binding and receptor internalization. IFN-gamma R2 is required for IFN-gamma signaling but does not bind IFN-gamma by itself. Human IFN-gamma R1 cDNA encodes a 499 amino acid (aa) residue protein with a 17 aa signal peptide, a 228 aa extracellular domain, a 23 aa transmembrane domain, and a 221 aa intracellular domain. Human and mouse IFN-gamma R1 share 52% amino acid sequence similarity and bind IFN-gamma in a species-specific manner. IFN-gamma R1 is constitutively expressed in most cell types. Soluble IFN-gamma R1 that binds IFN-gamma has been detected in biological fluids. The recombinant soluble IFN-gamma R1 produced has been shown to bind IFN-gamma with high affinity and is a potent IFN-gamma antagonist.
Catalogue number: CABT-L301
Reactivities: Mouse
Hosts: Goat
Conjugates: Biotin
Gene: 15979
Target: IFNGR1
Isotype: IgG
Clonality: Polyclonal
Storage temp: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

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