Goat anti Mouse IL1RN polyclonal antibody

Cat no: CABT-L316

Supplier: Creative Diagnostics

0 reviews | Write a Review Pencil

Read More on Supplier Website

Description
Additional Information

Goat Anti-Mouse IL1RN polyclonal antibody for ELISA(Cap), WB. IL-1ra was originally isolated from the urine of patients with monocytic leukemia and has also been purified from adherent monocytes. The naturally-occurring, fully glycosylated form has an apparent molecular weight of about 25,000 Daltons. The protein shows 26% amino acid homology to IL-1 beta b and 19% homology to IL-1 alpha. It will compete with either factor for receptor binding, but does not interact with either one. Human IL-1ra will bind to both types of IL-1 receptor (I and II) on human cells. In mouse, IL-1 RII does not bind IL-1ra. The recombinant, non-glycosylated form of IL-1ra blocks binding of IL-1 to its receptor equally as well as the naturally-occurring, glycosylated form. The IL-1ra has been shown to block the inflammatory responses induced by IL-1 both in vitro and in vivo. Pre-clinical and clinical studies were done to test possible therapeutic applications for IL-1ra in the treatment of sepsis, rheumatoid arthritis and chronic myelogenous leukemia.

Catalogue number:	CABT-L316
Reactivities:	Mouse
Hosts:	Goat
Conjugates:	Unconjugated
Gene:	16181
Target:	IL1RN
Isotype:	IgG
Clonality:	Polyclonal
Storage temp:	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

See Full Product Listings >

Goat anti Mouse IL1RN polyclonal antibody

Cat no: CABT-L316

Get Quote

About Biosave

Product Categories

Information


Get a Quote Direct from Creative Diagnostics




By submitting this form you agree to your details being passed to Creative Diagnostics for the purpose of generating the best quote*