Goat anti Mouse TREM1 polyclonal antibody

Cat no: CABT-L326

Supplier: Creative Diagnostics

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Goat Anti-Mouse TREM1 polyclonal antibody for ELISA(Cap), FC, Func, ICC/IF, WB. TREM-1 (Triggering Receptor Expressed on Myeloid cells) is a type I transmembrane protein having a single Ig-like domain. It associates with the adapter protein, DAP12, to deliver an activating signal. Several other TREM family members have been reported that are structurally similar but share less than 30% amino acid identity. TREM-1 is expressed on blood neutrophils and a subset of monocytes, and expression is up-regulated by bacterial LPS. Engagement of TREM-1 with a monoclonal antibody leads to expression of IL-8, MCP-1, and TNF-alpha suggesting that this receptor plays an important role in inflammatory responses. TREM-1 is expressed at high levels on neutrophils of patients with microbial sepsis and in mice with LPS-induced shock. Blockade of TREM-1 with a TREM-1/Fc fusion protein protected mice against LPS-induced shock.

Catalogue number:	CABT-L326
Reactivities:	Mouse
Hosts:	Goat
Conjugates:	Unconjugated
Gene:	58217
Target:	TREM1
Isotype:	IgG
Clonality:	Polyclonal
Storage temp:	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

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Goat anti Mouse TREM1 polyclonal antibody

Cat no: CABT-L326

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