Goat anti Rat IL10 polyclonal antibody [Biotin]

Goat Anti-Rat IL10 polyclonal antibody for ELISA(Det), WB. Interleukin 10, also known as cytokine synthesis inhibitory factor (CSIF), is the charter member of the IL-10 family of alpha-helical cytokines that also includes IL-19, IL-20, IL-22, and IL-24. IL-10 is secreted by many activated hematopoietic cell types as well as hepatic stellate cells, keratinocytes, and placental cytotrophoblasts. Mature rat IL-10 shares 85% amino acid sequence identity with mouse and 71%-79% amino acid sequence identity with bovine, canine, equine, feline, human, ovine, and porcine IL-10. Whereas human IL-10 is active on mouse cells, mouse IL-10 does not act on human cells. IL-10 is a 178 amino acid molecule that contains two intrachain disulfide bridges and is expressed as a 36 kDa noncovalently associated homodimer. The IL-10 dimer binds to two IL-10 R alpha /IL-10 R1 chains, resulting in recruitment of two IL-10 R beta b/IL-10 R2 chains and activation of a signaling cascade involving JAK1, TYK2, and STAT3. IL-10 R betadoes not bind IL-10 by itself but is required for signal transduction. IL-10 R beta also associates with IL-20 R alpha, IL-22 R alpha, or IL-28 R alpha to form the receptor complexes for IL-22, IL-26, IL-28, and IL-29. IL-10 is a critical molecule in the control of viral infections and allergic and autoimmune inflammation. It promotes phagocytic uptake and Th2 responses but suppresses antigen presentation and Th1 proinflammatory responses.

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SPECIFICATIONS

Catalog Number

CABT-L364

Hosts

Goat

Reactivities

Rat

Conjugates

Biotin

Target

IL10

Gene Id

25325

Isotype

IgG

Clonality

Polyclonal

Storage Temp

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 В°C as supplied. 1 month, 2 to 8 В°C under sterile conditions after reconstitution. 6 months, -20 to -70 В°C under sterile conditions after reconstitution.