Goat anti Rat IL1B polyclonal antibody

Goat Anti-Rat IL1B polyclonal antibody for ELISA(Cap), ICC/IF, WB. IL-1 is a name that designates two pleiotropic cytokines, IL-1 alpha(IL-1F1) and IL-1 beta(IL-1F2), which are the products of distinct genes. IL-1 alpha and IL-1 beta are structurally related polypeptides that share approximately 26% amino acid (aa) identity in rat. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL-1 alpha and IL-1 beta are regulated independently, they bind to the same receptor and exert identical biological effects. IL-1 RI binds directly to IL-1 alpha or IL-1 beta b and then associates with IL-1 R accessory protein (IL-1 R3/IL-1 R AcP) to form a high-affinity receptor complex that is competent for signal transduction. IL-1 RII has high affinity for IL-1 beta but functions as a decoy receptor and negative regulator of IL-1 beta activity. IL-1ra functions as a competitive antagonist by preventing IL-1 alpha and IL-1 beta from interacting with IL-1 RI. The rat IL-1 beta cDNA encodes a 268 aa precursor. A 116 aa propeptide is cleaved intracellularly by the cysteine protease IL-1 beta-converting enzyme (Caspase-1/ICE) to generate the active cytokine. The 17 kDa mature rat IL-1 beta b shares 90% aa sequence identity with cotton rat and mouse and 65-77% with canine, equine, feline, human, porcine, and rhesus macaque IL-1 beta.

Prices direct from Creative Diagnostics

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

CABT-L340

Hosts

Goat

Reactivities

Rat

Conjugates

Unconj

Target

IL1B

Gene Id

24494

Isotype

IgG

Clonality

Polyclonal

Storage Temp

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 В°C as supplied. 1 month, 2 to 8 В°C under sterile conditions after reconstitution. 6 months, -20 to -70 В°C under sterile conditions after reconstitution.