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Golgi protein 58K (Formiminotransferase cyclodeaminase, FTCD, Glutamate formiminotransferase, LCHC1)

Golgi protein 58K (Formiminotransferase cyclodeaminase, FTCD, Glutamate formiminotransferase, LCHC1)

Cat no: G8577-50D

Supplier: United States Biological
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58K protein antibodies are excellent for use as markers for the Golgi complex. The 58K protein has been identified as being FTCD, a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Defects in FTCD are the cause of glutamate formiminotransferase deficiency; also known as formiminoglutamicaciduria (FIGLU-uria). It is an autosomal recessive disorder. Features of a severe phenotype, include elevated levels of formiminoglutamate (FIGLU) in the urine in response to histidine administration, megaloblastic anemia, and mental retardation. Features of a mild phenotype include high urinary excretion of FIGLU in the absence of histidine administration, mild developmental delay, and no hematological abnormalities. Cellular Localization: Cytoplasmic and Golgi Apparatus Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:32,000 Western Blot: 0.03-0.1ug/ml. Predicted molecular weight: 59kD. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: G8577-50D
Reactivities: Human
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in TBS, pH 7.2, 0.5% BSA.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: Formiminotransferase cyclodeaminase, FTCD, Glutamate formiminotransferase, LCHC1
References: Bloom GS & Brashear TA A novel 58-kDa protein associates with the Golgi apparatus and microtubules. J Biol Chem 264:16083-92 (1989).
Additional info: Expected to recognize both reported isoforms. Species Crossreactivity: Reacts with Human. Predicted to react with Mouse (100% identity with immunogen), Rat (100% identity with immunogen), Chicken (84% identity with immunogen), Zebrafish (90% identity with immunogen) and porcine (100% identity with immunogen) due to sequence homology.

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