Gonadotropin-releasing Hormone Receptor (GnRH Receptor, GNRHR, GnRH-R, GRHR, GNRHR1, LHRHR, LRHR)

GnRHR is a Releasing-Hormone Receptor activated by gonadotropin-releasing hormone (GnRH). This receptor plays a major role in the regulation of reproductive functions. It modulates the synthesis and secretion of gonadotropin hormones such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary. In turn, LH and FSH regulate the release of steroid hormones from the gonads. Mutations in GnRHR have been linked to hypogonadotropic hypogonadism, a condition characterized by absence or delayed puberty and retarded bone maturation. GnRHR has been reported to be expressed mostly in the pituitary gonadotropes and in reproductive organs, including ovary, placenta, prostate, testis, and uterus. It is also expressed in breast, heart, kidney, liver, skeletal muscle, and thymus. No human ESTs have been isolated for this receptor.\n\nApplications:\nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:32,000\nWestern Blot: 0.5-1.5ug/ml, observed in human lysates of peripheral blood mononucleocytes on ~60kD bands\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

G8576-02K

Size

100ug

Applications

ELISA, WB

Hosts

Goat

Reactivities

Hum, Can

Form

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

References

1. Yeung CM, An BS, Cheng CK, Chow BK, Leung PC. Expression and transcriptional regulation of the GnRH receptor gene in human neuronal cells. Mol Hum Reprod. 2005 Nov;11(11):837-42. Epub 2005 Dec 19.

Additional Info

Recognizes human GNRHR. Species sequence homology: Canine.